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| Product Name: |
Legit Sarms Powder Acadesine/Aicar 2627-69-2
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| Supply Ability: |
800kg/week |
| Related proudcts |
aicar, acadesine, |
| Specifications |
1kg/bag |
| Price Term: |
FOB |
| Port of loading: |
SHENZHEN |
| Minimum Order |
10g |
| Unit Price: |
usd3/gram |
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CAS:2627-69-2
MF: C9H14N4O5
MW:258.23
EINECS:220-097-5
Synonyms:ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-***RBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-***RBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-***RBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE,Raw Material Sarms Powder
Melting point:214-215 °C
storage temp. �0°C
solubility H2O: >10 mg/mL
form powder
color tan
Water Solubility Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml
Description:
AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.
Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.
3. Function:
AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-***rboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, |
| Company: |
Jinan Jia Ge Biological Technology Co.,LTD
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| Contact: |
Ms. Sally Zhang |
| Address: |
Room 1804, Unit 1, Building 19 |
| Postcode: |
266555 |
| Tel: |
86 17753110973 |
| Fax: |
86 17753110973 |
| E-mail: |
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